口腔医学丙型肝炎病毒血清学阳性患者唾液中丙型肝炎病毒核糖核酸的出现情况
HCV-RNA occurrence in saliva of odontoiatric HCV seropositive patients.
作者信息
Savoldi E, Gargiulo F, Marinone M G, Favilli F, Callea F, Sapelli P L, Turano A
机构信息
Odontoiatric Clinic, Università degli Studi, Brescia, Italy.
出版信息
Minerva Stomatol. 2001 Mar-Apr;50(3-4):71-4.
BACKGROUND
HCV-RNA occurrence in saliva of patients suffering from C hepatitis induced to consider saliva as a possible diffusion mean of this disease.
METHODS
Saliva and blood samples from 32 C hepatitis seropositive patients, followed for odontostomatologic problems in Odontoiatric Clinic of Brescia University were obtained. In every blood and saliva sample HCV-RNA concentration was evaluated following HCV-RNA 2.0 Assay (bDNA) Quantiplex test (Chiron), in Microbiology Institute of Brescia University.
RESULTS
All patients showing HCV-RNA in serum presented virus in saliva also; two patients with negative HCV-RNA serum presented virus in saliva. In latter cases, we supposed that viral concentration in serum was under sensibility threshold of employed method.
CONCLUSIONS
Saliva appears an easily and not invasively obtainable medium for epidemiological studies on HCV diffusion in humans. Its role in C hepatitis transmission, on the contrary, has not been cleared till now.
背景
丙型肝炎患者唾液中丙型肝炎病毒核糖核酸（HCV-RNA）的出现促使人们考虑将唾液作为该疾病一种可能的传播途径。
方法
采集了32例丙型肝炎血清学阳性患者的唾液和血液样本，这些患者在布雷西亚大学牙科学院牙科诊所因口腔问题接受随访。在布雷西亚大学微生物研究所，采用HCV-RNA 2.0检测（分支DNA）定量检测法（Chiron）对每份血液和唾液样本中的HCV-RNA浓度进行评估。
结果
所有血清中检测出HCV-RNA的患者，其唾液中也检测出病毒；两名血清HCV-RNA阴性的患者，其唾液中检测出病毒。在后一种情况下，我们推测血清中的病毒浓度低于所用方法的检测阈值。
结论
唾液似乎是一种用于丙型肝炎病毒在人群中传播的流行病学研究的易于获取且非侵入性的介质。相反，其在丙型肝炎传播中的作用至今尚未明确。
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