卡托普利的中枢注射可抑制对脑室内胆碱的血压反应。

Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline.

作者信息

Isbil-Buyukcoskun N, Gulec G, Ozluk K, Ulus I H

机构信息

Departments of Physiology, Uludag University Medical Faculty, 16059 Gorukle, Bursa, Turkey.

出版信息

Braz J Med Biol Res. 2001 Jun;34(6):815-20. doi: 10.1590/s0100-879x2001000600018.

DOI:10.1590/s0100-879x2001000600018

PMID:11378673

Abstract

In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of intracerebroventricular (icv) choline (50, 100 and 150 microg) on blood pressure. Choline increased blood pressure in a dose-dependent manner. In order to investigate the effects of brain renin-angiotensin system blockade on blood pressure increase induced by choline (150 microg, icv), an angiotensin-converting enzyme inhibitor, captopril (25 and 50 microg, icv), was administered 3 min before choline. Twenty-five microg captopril did not block the pressor effect of choline, while 50 microg captopril blocked it significantly. Our results suggest that the central renin-angiotensin system may participate in the increase in blood pressure induced by icv choline in normotensive rats.

摘要

在本研究中，我们调查了脑肾素-血管紧张素系统在中枢胆碱能刺激对清醒、自由活动的正常血压大鼠血压影响中的作用。第一步，我们确定了脑室内（icv）注射胆碱（50、100和150微克）对血压的影响。胆碱以剂量依赖的方式升高血压。为了研究脑肾素-血管紧张素系统阻断对胆碱（150微克，icv）诱导的血压升高的影响，在注射胆碱前3分钟给予血管紧张素转换酶抑制剂卡托普利（25和50微克，icv）。25微克卡托普利未阻断胆碱的升压作用，而50微克卡托普利则显著阻断了该作用。我们的结果表明，中枢肾素-血管紧张素系统可能参与了正常血压大鼠icv注射胆碱诱导的血压升高。