Holtzman S G
Psychopharmacology (Berl). 1979 Jun 21;63(3):207-9. doi: 10.1007/BF00433551.
Lever-pressing by squirrel monkeys was maintained under a continuous avoidance schedule in which each response postponed for 30 s the delivery of an electric shock to the tail. Dose-response curves were determined for chlorpromazine (0.03--0.3 mg/kg) and d-amphetamine (0.03--1.0 mg/kg) administered alone and administered concomitantly with 1.0 or 10 mg/kg of naloxone. The dose-response curves for chlorpromazine and d-amphetamine were similar to those previously reported for monkeys under other schedules of shock-maintained behavior: Chlorpromazine decreased responding in a dose-related manner while d-amphetamine increased responding at low doses and disrupted behavior at the highest dose. Naloxone did not modify the effects of chlorpromazine and d-amphetamine. These results suggest that interactions observed previously between naloxone and nonopiate drugs on behavior in pigeons and rodents are not general phenomena in all animal species.
松鼠猴的压杆行为在持续回避程序下得以维持，在该程序中，每次反应会使电击尾巴的时间推迟30秒。分别测定了单独给予氯丙嗪（0.03 - 0.3毫克/千克）和右旋苯丙胺（0.03 - 1.0毫克/千克）以及与1.0或10毫克/千克纳洛酮同时给药时的剂量反应曲线。氯丙嗪和右旋苯丙胺的剂量反应曲线与先前在其他电击维持行为程序下对猴子所报道的曲线相似：氯丙嗪以剂量相关的方式减少反应，而右旋苯丙胺在低剂量时增加反应，在最高剂量时扰乱行为。纳洛酮并未改变氯丙嗪和右旋苯丙胺的作用。这些结果表明，先前观察到的纳洛酮与非阿片类药物在鸽子和啮齿动物行为上的相互作用并非在所有动物物种中都是普遍现象。
