Papadimitriou A, Nicolaidou P, Garoufi A, Georgouli H, Karpathios T
Second Department of Pediatrics, P&A Kyriakou Children's Hospital, Athens, Greece.
Pediatr Int. 2001 Jun;43(3):231-4. doi: 10.1046/j.1442-200x.2001.01386.x.
The purpose of the present study was to investigate whether idiopathic hypercalciuria may be implicated in the pathogenesis of febrile convulsions.
We studied 38 children (22 boys) with febrile convulsions (mean (+/- SD) age 3.25 +/- 1.09 years) and 45 healthy children (28 boys) of similar age who served as controls. Twenty-four hour urine calcium and phosphate, as well as serum calcium, phosphate, alkaline phosphatase and intact parathyroid hormone (PTH) concentrations were determined.
Hypercalciuria (urine Ca >4.0 mg/kg bodyweight per 24 h) was found in nine children with febrile convulsions (23.7%) and in three controls (6.7%). Hypercalciuric children excreted significantly more phosphate in their urine (37.0 +/- 11.6 mg/kg bodyweight per 24 h) than normocalciuric children (18.7 +/- 8.7 mg/kg bodyweight per 24 h) and controls (20.2 +/- 7.6 mg/kg bodyweight per 24 h). They also had higher serum intact PTH concentrations (49.87 +/- 15.36 pg/mL) than normocalciuric (35.39 +/- 15.67 pg/mL) and control children (28.21 +/- 14.00 pg/mL). According to the calcium-loading test, eight of nine children with hypercalciuria had the renal type of the disorder. Furthermore, hypercalciuric children had significantly more convulsive episodes (2.77 +/- 1.98) than normocalciuric children (1.86 +/- 1.24).
Our results suggest that renal hypercalciuria may be implicated in the pathogenesis of febrile convulsions.
本研究旨在探讨特发性高钙尿症是否可能与热性惊厥的发病机制有关。
我们研究了38名热性惊厥患儿（22名男孩）（平均（±标准差）年龄3.25±1.09岁）以及45名年龄相仿的健康儿童（28名男孩）作为对照。测定了24小时尿钙和尿磷以及血清钙、磷、碱性磷酸酶和完整甲状旁腺激素（PTH）的浓度。
9名热性惊厥患儿（23.7%）和3名对照儿童（6.7%）存在高钙尿症（尿钙>4.0mg/kg体重/24小时）。高钙尿症患儿尿中排出的磷（37.0±11.6mg/kg体重/24小时）明显多于正常钙尿症患儿（18.7±8.7mg/kg体重/24小时）和对照儿童（20.2±7.6mg/kg体重/24小时）。他们的血清完整PTH浓度（49.87±15.36pg/mL）也高于正常钙尿症患儿（35.39±15.67pg/mL）和对照儿童（28.21±14.00pg/mL）。根据钙负荷试验，9名高钙尿症患儿中有8名属于肾性疾病类型。此外，高钙尿症患儿的惊厥发作次数（2.77±1.98）明显多于正常钙尿症患儿（1.86±1.24）。
我们的结果表明肾性高钙尿症可能与热性惊厥的发病机制有关。
