Nakazawa M, Tawaratani T, Uchimoto H, Kawaminami A, Ueda M, Ueda A, Shinoda Y, Iwakura K, Kura K, Sumi N
Research Laboratories, Nippon Shinyaku Co., Ltd., 14 Nishinosho-Monguchicho Kisshoin, Minami-ku, Kyoto 601-8550, Japan.
Exp Anim. 2001 Apr;50(2):99-103. doi: 10.1538/expanim.50.99.
Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7% and 87 to 95.8% in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in males and mammary gland tumors, thyroidal C-cell adenoma and uterine stromal polyp in females.
在5周龄开始的整个生命周期中，未治疗的老年斯普拉格-道利（SD）大鼠身上观察到肿瘤性病变。它们的平均存活时间为89至105周龄。雄性和雌性的总肿瘤发生率分别为70%至76.7%和87%至95.8%。常见的肿瘤在两性中均为垂体腺瘤和肾上腺嗜铬细胞瘤，雄性为睾丸间质细胞瘤，雌性为乳腺肿瘤、甲状腺C细胞腺瘤和子宫间质息肉。
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