全身性给予下丘脑泌素-1可减少发作性睡病犬的猝倒现象，并使睡眠和清醒时长恢复正常。
Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs.
作者信息
John J, Wu M F, Siegel J M
机构信息
Department of Psychiatry and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA.
出版信息
Sleep Res Online. 2000;3(1):23-8.
Abstract
Recent work has implicated the hypocretin (orexin) system in the genesis of narcolepsy. In the current study we demonstrate that systemically administered hypocretin-1 (Hcrt-1) produces an increase in activity level, longer waking periods, a decrease in REM sleep without change in nonREM sleep, reduced sleep fragmentation and a dose dependent reduction in cataplexy in canine narcoleptics. Repeated administration of single daily doses of Hcrt-1 led to consolidation of waking and sleep periods and to a complete loss of cataplexy for periods of three or more days after treatment in animals that were never asymptomatic under control conditions. Systemic administration of Hcrt-1 may be an effective treatment for narcolepsy.
摘要
最近的研究表明，下丘脑分泌素（食欲素）系统与发作性睡病的发病机制有关。在本研究中，我们证明，对犬发作性睡病患者全身给予下丘脑分泌素-1（Hcrt-1）可使活动水平增加、清醒时间延长、快速眼动睡眠减少而非快速眼动睡眠无变化、睡眠片段化减少，且猝倒症状呈剂量依赖性减轻。在对照条件下从未无症状的动物中，每日单次重复给予Hcrt-1可导致清醒和睡眠时间巩固，并在治疗后三天或更长时间内完全消除猝倒症状。全身给予Hcrt-1可能是治疗发作性睡病的有效方法。
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