蓝斑神经元：发作性睡病猝倒期间活动停止。
Locus coeruleus neurons: cessation of activity during cataplexy.
作者信息
Wu M F, Gulyani S A, Yau E, Mignot E, Phan B, Siegel J M
机构信息
Neurobiology Research, VA Medical Center, North Hills, CA 91343, USA.
出版信息
Neuroscience. 1999;91(4):1389-99. doi: 10.1016/s0306-4522(98)00600-9.
Cataplexy, a symptom of narcolepsy, is a loss of muscle tone usually triggered by sudden, emotionally significant stimuli. We now report that locus coeruleus neurons cease discharge throughout cataplexy periods in canine narcoleptics. Locus coeruleus discharge rates during cataplexy were as low as or lower than those seen during rapid-eye-movement sleep. Prazosin, an alpha1 antagonist, and physostigmine, a cholinesterase inhibitor, both of which precipitate cataplexy, decreased locus coeruleus discharge rate. Our results are consistent with the hypothesis that locus coeruleus activity contributes to the maintenance of muscle tone in waking, and that reduction in locus coeruleus discharge plays a role in the loss of muscle tone in cataplexy and rapid-eye-movement sleep. Our results also show that the complete cessation of locus coeruleus activity is not sufficient to trigger rapid-eye-movement sleep in narcoleptics.
猝倒症是发作性睡病的一种症状，通常由突然的、具有情感意义的刺激引发肌肉张力丧失。我们现在报告，在犬发作性睡病患者的猝倒发作期间，蓝斑神经元会停止放电。猝倒发作期间蓝斑的放电率与快速眼动睡眠期间的放电率一样低或更低。α1拮抗剂哌唑嗪和胆碱酯酶抑制剂毒扁豆碱都会引发猝倒症，二者均降低了蓝斑的放电率。我们的结果与以下假设一致：蓝斑活动有助于维持清醒时的肌肉张力，而蓝斑放电减少在猝倒症和快速眼动睡眠时的肌肉张力丧失中起作用。我们的结果还表明，蓝斑活动完全停止不足以触发发作性睡病患者的快速眼动睡眠。
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