Klimov A N, Vasil'eva L E, Petrova L A, Poliakova E D, Riazanova T V
Vopr Med Khim. 1975 Mar-Apr;21(2):189-92.
Aromatic derivatives of mevalonic acid (2-phenyl-3-methyl-3-hydroxy pentanic and 2,3-diphenyl-3-hydroxy pentanic acids) decreased the yield of unesterified fatty acids from adipose tissue by about 28-36 percent after subcutaneous administration into rats within one or two weeks and under conditions of incubation of the adipose tissue in vitro. Distinct decrease in the yield of glycerol was cause by 2,3-diphenyl-3-hydroxy pentanic acid (1 with 10-minus 3 = 5 with 10-minus 3 M) under conditions of lipolysis stimulated by adrenaline. Antilipolytic effect of the preparation was more pronounced than that of well-known hypolipidemic drug clofibrate (p-chlorophenhydroxy isobutyrate).
甲羟戊酸的芳香族衍生物（2-苯基-3-甲基-3-羟基戊酸和2,3-二苯基-3-羟基戊酸）在大鼠皮下给药一至两周内以及在体外脂肪组织孵育条件下，可使脂肪组织中未酯化脂肪酸的产量降低约28% - 36%。在肾上腺素刺激脂解的条件下，2,3-二苯基-3-羟基戊酸（1×10⁻³ = 5×10⁻³M）可导致甘油产量明显下降。该制剂的抗脂解作用比著名的降血脂药物氯贝丁酯（对氯苯氧异丁酸）更显著。
