Kriukova E N, Karpushev A V, Frolova S A, Fedin A N
St. Petersburg State University, 199034, St. Petersburg, Universitetskaya Nab., 7/9, Russia.
Ross Fiziol Zh Im I M Sechenova. 2001 Mar;87(3):410-7.
Histamine produced either a bronchodilation or a bronchoconstriction in rats. In a 0.01-1.0 mcg/ml concentration histamine augmented the contractions amplitude in electrical stimulation of the trachea, in a 10-100 mcg/ml concentration histamine enhances the muscle tone thus decreasing the induced contractions. The histamine effects seems to be connected with its prevailing influence on different structures of the airways depending on the concentration. Its high concentrations act directly on the smooth muscle whereas its lower concentration affects receptors signaling the functional modules of the metasympathetic nervous system within the intramural ganglia of the trachea.
组胺在大鼠中可引起支气管扩张或收缩。在浓度为0.01 - 1.0微克/毫升时，组胺可增强气管电刺激时的收缩幅度；在浓度为10 - 100微克/毫升时，组胺可增强肌张力，从而减少诱发的收缩。组胺的作用似乎与其根据浓度对气道不同结构的主要影响有关。高浓度组胺直接作用于平滑肌，而低浓度组胺则影响气管壁内神经节中传递交感性神经系统功能模块信号的受体。
