Baraka A
Br J Anaesth. 1975 Mar;47(3):416-8. doi: 10.1093/bja/47.3.416.
This report describes the potentiation of a suxamethonium-induced (0.1 mg/kg) neuromuscular block in two children with atypical serum cholinesterase activity, and compares it with a control response demonstrated in a homozygote brother. In the atypical homozygote patients, suxamethonium produced a markedly prolonged neuromuscular block associaiated with partial desensitizatin as evidenced by tetanic fade and post-tetanic facilitation. The use of neostigmine 0.05 mg/kg for reversal was followed by a paradoxical potentiation of the block and a marked delay in recovery. It is suggested that in atypical homozygotes, the development of desensitization after suxamethonium does not necessarily imply that the block will be reversed with neostigmine.
本报告描述了两名血清胆碱酯酶活性异常的儿童对琥珀胆碱诱导的（0.1mg/kg）神经肌肉阻滞的增强作用，并将其与一名纯合子兄弟的对照反应进行了比较。在非典型纯合子患者中，琥珀胆碱产生了明显延长的神经肌肉阻滞，并伴有部分脱敏现象，如强直刺激衰减和强直后易化所证明的那样。使用0.05mg/kg新斯的明进行逆转后，出现了阻滞的反常增强和恢复的明显延迟。提示在非典型纯合子中，琥珀胆碱后脱敏的发生并不一定意味着新斯的明能逆转阻滞。
