Abo M, Chen Z, Lai L J, Reese T, Bjelke B
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Neuroreport. 2001 May 25;12(7):1543-7. doi: 10.1097/00001756-200105250-00048.
Behavioral recovery takes place even after permanent damage to the entire brain region normally controlling sensorimotor hind limb function in the rat. In our study, 2 weeks after full behavioral recovery from an experimental unilateral permanent brain damage, the topographic representation of the previous paretic hindlimb was investigated by fMRI. The analysis showed that during electrical stimulation of the previously paretic hindlimb, two normally inactive brain regions were now being activated. One region was the non-damaged contralateral sensori-motor cortex and the other region was located lateral to the lesion. These results suggest that behavioral recovery can be explained by functional reorganization and neuromodulation of the brain.
即使大鼠中通常控制感觉运动后肢功能的整个脑区受到永久性损伤，行为恢复仍会发生。在我们的研究中，从实验性单侧永久性脑损伤完全行为恢复2周后，通过功能磁共振成像（fMRI）研究了先前麻痹后肢的地形表示。分析表明，在对先前麻痹的后肢进行电刺激时，两个通常不活跃的脑区现在被激活了。一个区域是未受损的对侧感觉运动皮层，另一个区域位于损伤部位的外侧。这些结果表明，行为恢复可以通过大脑的功能重组和神经调节来解释。
