Higaki J, Katsuya T, Ogihara T
Department of Geriatric Medicine, Osaka University Graduate School of Medicine.
Nihon Rinsho. 2001 May;59(5):847-52.
Essential hypertension is a multifactorial disease which is evoked by multiple environmental and genetic factors. Recent progress in molecular biology enables us a comprehensive understanding of the molecular pathogenesis of this disease. The genes of renin-angiotensin system such as renin, angiotensinogen, angiotensin-converting enzyme and angiotensin receptors genes are all reported as positive linkage to hypertension. Now ongoing progress of the human genome project will further accelerate the molecular studies on the rennin-angiotensin system and hypertension.
原发性高血压是一种由多种环境和遗传因素引发的多因素疾病。分子生物学的最新进展使我们能够全面了解这种疾病的分子发病机制。肾素-血管紧张素系统的基因，如肾素、血管紧张素原、血管紧张素转换酶和血管紧张素受体基因，均被报道与高血压存在正向关联。目前人类基因组计划的不断推进将进一步加速对肾素-血管紧张素系统和高血压的分子研究。
