A facile synthesis of 5'-end solid-anchored, 3'-end free oligodeoxyribonucleotides via the (5'-->3')-elongated phosphoramidite strategy.
作者信息
Sakakura A, Hayakawa Y
机构信息
Laboratory of Bioorganic Chemistry, Graduate School of Human Informatics, Nagoya University, Chikusa, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2001 Mar;20(3):213-27. doi: 10.1081/NCN-100002082.
PMID:11393398
Abstract
It is demonstrated that not only N2- but also O6-protection of the guanine base is necessary for obtaining the oligodeoxyribonucleotides in high yields and at a high purity in the solid-phase synthesis via the (5'--> 3')-chain elongated phosphoramidite approach.
摘要
Zotero 插件