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通过康普顿反冲电子传输解析确定的探测器线扩展函数。

Detector line spread functions determined analytically by transport of Compton recoil electrons.

作者信息

van't Veld A A, van Luijk P, Praamstra F, van der Hulst P C

机构信息

Groningen University Hospital, Department of Radiation Oncology, The Netherlands.

出版信息

Med Phys. 2001 May;28(5):738-51. doi: 10.1118/1.1366665.

Abstract

To achieve the maximum benefit of conformal radiation therapy it is necessary to obtain accurate knowledge of radiation beam penumbras based on high-resolution relative dosimetry of beam profiles. For this purpose there is a need to perform high-resolution dosimetry with well-established routine dosimeters, such as ionization chambers or diodes. Profiles measured with these detectors must be corrected for the dosimeter's nonideal response, caused by finite dimensions and, in the case of an ionization chamber, the alteration of electron transport and a contribution of electrons recoiled in the chamber wall and the central electrode. For this purpose the line spread function (LSF) of the detector is needed. The experimental determination of LSFs is cumbersome and restricted to the specific detector and beam energy spectrum used. Therefore, a previously reported analytical model [Med. Phys. 27, 923-934 (2000)] has been extended to determine response profiles of routine dosimeters: shielded diodes and, in particular, ionization chambers, in primary dose slit beams. The model combines Compton scattering of incident photons, the transport of recoiled electrons by Fermi-Eyges small-angle multiple scattering theory, and functions to limit electron transport. It yields the traveling direction and the energy of electrons upon incidence on the detector surface. In the case of ionization chambers, geometrical considerations are then sufficient to calculate the relative amount of ionization in chamber air, i.e., the detector response, as a function of the detector location in the slit beam. In combination with the previously reported slit beam dose profiles, the LSF can then readily be derived by reconstruction techniques. Since the spectral contributions are preserved, the LSF of a dosimeter is defined for any beam for which the effective spectrum is known. The detector response profiles calculated in this study have been verified in a telescopic slit beam geometry, and were found to correspond to experimental profiles within 0.2 and 0.3 mm (full width at half-maximum) for a Wellhoefer IC15 chamber in a 6 and 25 MV-X x-ray beam, respectively. For a shielded diode these figures were found to be 0.2 and 0.1 mm, respectively. It is shown that a shielded diode in a primary beam needs only a small size-based correction of measured profiles. The effect of the LSF of an IC15 chamber on penumbra width has been determined for a set of model penumbras. The LSFs calculated by the application of the analytical model yield a broadening by 2 mm of a 3 mm wide penumbra (20%-80%). This is 0.5 mm (6 MV-X) to 1 mm (25 MV-X) smaller than found with the experimental LSFs. With a spatial correction based on the LSFs that were determined in this study, this broadening of up to 2 mm is eliminated, so that ionization chambers like the IC15 can be used for high-resolution relative dosimetry on a routine basis.

摘要

为了实现适形放射治疗的最大益处,有必要基于射束剖面的高分辨率相对剂量测定法,准确了解辐射束半值层。为此,需要使用成熟的常规剂量仪(如电离室或二极管)进行高分辨率剂量测定。用这些探测器测量的剖面必须针对剂量仪的非理想响应进行校正,这种非理想响应是由有限尺寸引起的,对于电离室而言,还包括电子输运的改变以及在室壁和中心电极中反冲电子的贡献。为此,需要探测器的线扩展函数(LSF)。LSF的实验测定既繁琐又局限于所使用的特定探测器和射束能谱。因此,已对先前报道的一个分析模型[《医学物理》27, 923 - 934 (2000)]进行扩展,以确定常规剂量仪(屏蔽二极管,特别是电离室)在原发射线狭缝射束中的响应剖面。该模型结合了入射光子的康普顿散射、费米 - 艾格斯小角多重散射理论对反冲电子的输运以及限制电子输运的函数。它能得出电子入射到探测器表面时的行进方向和能量。对于电离室,通过几何考虑就足以计算室空气中电离的相对量,即探测器响应,作为探测器在狭缝射束中位置的函数。结合先前报道的狭缝射束剂量剖面,然后可通过重建技术轻松推导出LSF。由于保留了光谱贡献,对于有效能谱已知的任何射束,都可以定义剂量仪的LSF。本研究中计算的探测器响应剖面已在望远镜式狭缝射束几何结构中得到验证,结果发现,对于Wellhoefer IC15室,在6和25 MV - X X射线射束中,其与实验剖面的对应在半高宽处分别为0.2和0.3 mm。对于屏蔽二极管,这些数值分别为0.2和0.1 mm。结果表明,原发射束中的屏蔽二极管只需对测量剖面进行基于尺寸的小校正。已针对一组模型半值层确定了IC15室的LSF对半值层宽度的影响。应用分析模型计算得到的LSF使3 mm宽的半值层(20% - 80%)展宽2 mm。这比实验LSF得到的结果小0.5 mm(6 MV - X)至1 mm(25 MV - X)。基于本研究中确定的LSF进行空间校正后,这种高达2 mm的展宽被消除,因此像IC15这样的电离室可常规用于高分辨率相对剂量测定。

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