Micklem H S, Ford C E, Evans E P, Ogden D A
Cell Tissue Kinet. 1975 May;8(3):219-32. doi: 10.1111/j.1365-2184.1975.tb01221.x.
Two chromosomally distinguishable haemopoietic cell populations were injected into lethally irradiated syngeneic recipients. The presence or absence of the T(14;15)6Ca reciprocal translocation (indicated by T6 marker chromosomes) did not affect the proliferation of a population. Wide disparities were found in the proportions of the two donor cell populations between animals and between the right and left femora of individual animals. This suggest (i) that there is, at most, a very limited interchange of proliferating cells and their precursors between the marrow of different bones; and (ii) that the number of clones proliferating in the bone marrow at any one time must be rather small; there was evidence that this number depended in part on the number of haemopoietic cells injected. Exchange between the mitotically active cell populations of spleen, thymus, lymph nodes and bone marrow was also limited, as shown by significant disparities in the proportions of the two donor populations proliferating in the different tissues of individual mice.
将两个染色体可区分的造血细胞群体注入经致死剂量照射的同基因受体中。T(14;15)6Ca相互易位（由T6标记染色体指示）的存在与否并不影响一个群体的增殖。在不同动物之间以及单个动物的左右股骨之间，两个供体细胞群体的比例存在很大差异。这表明：（i）不同骨骼的骨髓之间，增殖细胞及其前体的交换最多非常有限；（ii）任何时候在骨髓中增殖的克隆数量必定相当少；有证据表明这个数量部分取决于注入的造血细胞数量。脾脏、胸腺、淋巴结和骨髓中有丝分裂活跃细胞群体之间的交换也很有限，这在单个小鼠不同组织中增殖的两个供体群体比例存在显著差异中得到体现。
