Yang J H, Chen H F, Lien Y R, Chen S U, Ho H N, Yang Y S
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
J Reprod Med. 2001 May;46(5):434-8.
To investigate the influence of various estradiol (E2): oocyte ratios on reproductive outcome in women undergoing in vitro fertilization and tubal embryo transfer (IVF-TET).
Two hundred seven women undergoing 251 IVF-TET cycles were recruited in this retrospective study. All the women received a flare-up gonadotropin releasing hormone agonist (GnRHa) protocol to achieve ovarian hyperstimulation. Oocyte retrieval was performed 34-36 hours after human chorionic gonadotropin (hCG) injection, followed by TET two days later.
An E2: oocyte ratio > or = 350 pg/mL had a higher E2 level (2,213 +/- 2,258 vs. 1,553 +/- 972 pg/mL, P < .05) and fertilization rate (77 +/- 23 vs. 64 +/- 23%, P < .001) but a lower oocyte number (4.8 +/- 4.7 vs. 7.6 +/- 4.8, P < .001) than in those with a ratio < 350 pg/mL. The pregnancy (17.9% vs. 32.8%, P = .03) and implantation (5.3% vs. 12.9%, P = .008) rates were significantly decreased in cycles with an E2: oocyte ratio > or = 350 pg/mL as compared to those with a ratio < 350 pg/mL.
IVF-TET cycles with an elevated E2: oocyte ratio correlated with lower pregnancy and implantation rates. The poor reproductive outcome possibly was due to the relatively high E2 concentration, which might have a detrimental effect on endometrial receptivity.
探讨不同雌二醇（E2）与卵母细胞比例对接受体外受精和输卵管胚胎移植（IVF-TET）的女性生殖结局的影响。
本回顾性研究纳入了207例接受251个IVF-TET周期的女性。所有女性均接受促性腺激素释放激素激动剂（GnRHa）激发方案以实现卵巢过度刺激。在注射人绒毛膜促性腺激素（hCG）后34 - 36小时进行卵母细胞采集，随后在两天后进行输卵管胚胎移植（TET）。
E2与卵母细胞比例≥350 pg/mL的患者，其E2水平较高（2213±2258 vs. 1553±972 pg/mL，P <.05），受精率较高（77±23 vs. 64±23%，P <.001），但卵母细胞数量较少（4.8±4.7 vs. 7.6±4.8，P <.001），与比例<350 pg/mL的患者相比。与E2与卵母细胞比例<350 pg/mL的周期相比，E2与卵母细胞比例≥350 pg/mL的周期妊娠率（17.9% vs. 32.8%，P =.03）和着床率（5.3% vs. 12.9%，P =.008）显著降低。
E2与卵母细胞比例升高的IVF-TET周期与较低的妊娠率和着床率相关。生殖结局不佳可能是由于E2浓度相对较高，这可能对子宫内膜容受性产生不利影响。
