Meyer-Hermann M, Deutsch A, Or-Guil M
Institut für Theoretische Physik, Dresden, D-01062, Germany.
J Theor Biol. 2001 Jun 7;210(3):265-85. doi: 10.1006/jtbi.2001.2297.
We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the corresponding antibody types represented in a shape space, differentiation to centrocytes, selection with respect to initial antigens, differentiation of positively selected centrocytes to plasma or memory cells and recycling of centrocytes to centroblasts. We use exclusively parameters with a direct biological interpretation such that, once determined by experimental data, the model gains predictive power. Based on the experiment of Han et al. (1995b) we predict that a high rate of recycling of centrocytes to centroblasts is necessary for the germinal center reaction to work reliably. Furthermore, we find a delayed start of the production of plasma and memory cells with respect to the start of point mutations, which turns out to be necessary for the optimization process during the germinal center reaction. The dependence of the germinal center reaction on the recycling probability is analysed.
我们引入了一种用于生发中心中成纤维细胞和中心细胞动力学的新模型。该模型将生发中心反应简化为被视为基本要素的元素，并纳入了成纤维细胞的增殖、形状空间中所代表的相应抗体类型的点突变、向中心细胞的分化、针对初始抗原的选择、阳性选择的中心细胞向浆细胞或记忆细胞的分化以及中心细胞向成纤维细胞的循环利用。我们仅使用具有直接生物学解释的参数，这样一旦由实验数据确定，该模型就具有预测能力。基于Han等人（1995b）的实验，我们预测中心细胞向成纤维细胞的高循环率对于生发中心反应可靠运作是必要的。此外，我们发现相对于点突变的开始，浆细胞和记忆细胞的产生开始延迟，这对于生发中心反应期间的优化过程而言是必要的。我们分析了生发中心反应对循环概率的依赖性。
