Przewłocki T, Syty M, Ryniewicz W, Piatek J, Podolec P, Lelakowski J, Pieniazek P, Tracz W
Klinika Chorób Serca i Naczyń Instytutu Kardiologii CM UJ Krakowski Szpital Specjallstyczny im. Jana Pawła II 31-202 Kraków, ul. Pradnicka 80.
Przegl Lek. 2000;57(12):691-8.
Improvement in the quality of life is nowadays widely acknowledged as an important factor in assessment of the long-term outcome of the actually pursued treatment. Percutaneous transluminal coronary angioplasty (PTCA) has been used in the treatment of coronary disease in ca. 1/3 of patients. The present study aimed to assess the quality of life in 567 patients successfully treated by PTCA in the period 1987-1996. In the observation period spanning 2.5-12 years (5.5 years on average) 26 patients (4.6%) died. A specially designed questionnaire was sent out to the remaining 541 patients, in which they were asked to attempt a subjective assessment of their general health condition and physical fitness, as well as to comment on the quality of their family and social life following angioplasty. The filled-in questionnaire was returned by 447 patients (82.6%). Their functional status, assessed in compliance with the CCS criteria, was perceptibly improved after the procedure and at the end of the observation period 70.5% of patients had no significant coronary complaints. A durable improvement after PTCA was claimed by 85.7% of patients, for 38.2% the result of PTCA turned out to be much better than originally expected, while 47.9% admitted that the procedure actually complied with their expectations. No improvement whatsoever was reported by 11.8%, while 2.3% of patients claimed their condition to have deteriorated since. In their own assessment, normal sexual life after PTCA was still pursued by 63.1% of patients, though men appeared to be more active in that domain than women (68.0% vs. 44.7%, p = 0.0001). Notable improvement was reported by 15.2%, while deterioration was claimed by 17.2%; in both cases it was significantly more frequent in men (improvement 17.0% vs 8.5%, p = 0.042, deterioration 19.5% vs 8.5%, p = 0.012). Angioplasty had no impact on their social relations in 78.8% of patients, while 21.2% of them are commonly perceived as the disabled persons. The need for psychotherapy (counselling) was expressed by 15.9%. The analysis of the key factors determining the actual quality of life in patients, carried out in the sub-groups, did not yield significant differences between the patients with stable and unstable angina, patients below and over 50 years of age, patients with complete and incomplete revascularisation, nor in patients who experienced or not, cardiac events during the follow-up. The significant differences between men and women were encountered only with respect to their sexual life. Diabetics in comparison with non-diabetics significantly more frequently reported improvement in their sexual life, full resumption of their non-occupational activities, generally showed more appreciation for the overall outcome of the PTCA procedure. Diabetics much less frequently experienced improvement in their general physical fitness, generally regarded the need for regular medical check-ups as a hindrance, as well as were more frequently perceived as the disabled persons. The working status of the patients after angioplasty failed to improve, however, as nearly half of them, despite the successfully completed procedure, was granted disability pensions or took advantage of the voluntary retirement schemes. Only 7.2% of the non-working patients well within their statutory employment age successfully returned to their employment, although not on a full-time basis. Patients who had completed their primary or secondary education were found to leave their employment twice more frequently than the ones with academic education. Similarly, patients living in the rural areas or in small towns (less than 40.000 inhabitants) left their employment twice more frequently than the ones living in major cities.
Both the functional status of patients and the majority of the analysed factors determining the quality of life--in the subjective assessment of those patients--improved significantly after a successful PTCA. This improvement is irrespective of the patients' age, symptoms of unstable angina during the procedure, extensiveness of revascularisation as well as cardiac events during the follow-up. Nearly half of the working patients tend to leave their employment after a successful percutaneous revascularisation, while the non-working patients are seldom prompted to resume their employment by the successful procedure. Patients with academic education, living in major cities, are usually found to resume their original employment most frequently.
如今,生活质量的改善被广泛认为是评估当前所采用治疗方法长期疗效的一个重要因素。经皮腔内冠状动脉成形术(PTCA)已用于约三分之一冠心病患者的治疗。本研究旨在评估1987年至1996年期间567例成功接受PTCA治疗患者的生活质量。在为期2.5至12年(平均5.5年)的观察期内,26例患者(4.6%)死亡。向其余541例患者发放了一份专门设计的问卷,询问他们对自身总体健康状况和体能进行主观评估,并就血管成形术后的家庭和社会生活质量发表意见。447例患者(82.6%)返还了填写好的问卷。按照CCS标准评估,他们的功能状态在术后明显改善,在观察期末,70.5%的患者无明显冠心病症状。85.7%的患者声称PTCA后有持久改善,38.2%的患者认为PTCA的结果比预期好得多,而47.9%的患者承认该手术实际符合他们的期望。11.8%的患者报告毫无改善,而2.3%的患者声称自那以后病情恶化。据他们自己评估,63.1%的患者PTCA后仍有正常性生活,不过男性在这方面似乎比女性更活跃(68.0%对44.7%,p = 0.0001)。15.2%的患者报告有显著改善,17.2%的患者声称有恶化;在这两种情况下,男性的发生率均显著更高(改善:17.0%对8.5%,p = 0.042,恶化:19.5%对8.5%,p = 0.012)。78.8%的患者血管成形术对其社会关系无影响,而21.2%的患者通常被视为残疾人。15.9%的患者表示需要心理治疗(咨询)。在亚组中对决定患者实际生活质量的关键因素进行分析,结果显示稳定性心绞痛和不稳定性心绞痛患者、50岁以下和50岁以上患者、血管再通完全和不完全患者,以及随访期间发生或未发生心脏事件的患者之间均无显著差异。仅在性生活方面男性和女性存在显著差异。与非糖尿病患者相比,糖尿病患者更频繁地报告性生活改善、完全恢复非职业活动,总体上对PTCA手术的整体结果评价更高。糖尿病患者总体体能改善较少,通常认为定期体检是一种阻碍,并且更常被视为残疾人。血管成形术后患者的工作状态并未改善,然而,近一半患者尽管手术成功完成,仍领取残疾抚恤金或利用自愿退休计划。法定就业年龄内的非在职患者中只有7.2%成功恢复工作,尽管不是全职工作。完成小学或中学教育的患者离职的频率是受过高等教育患者的两倍。同样,生活在农村地区或小镇(居民少于40000人)的患者离职的频率是生活在大城市患者的两倍。
成功进行PTCA后,患者的功能状态以及大多数决定生活质量的分析因素——在患者的主观评估中——均有显著改善。这种改善与患者年龄、手术期间不稳定性心绞痛症状、血管再通范围以及随访期间的心脏事件无关。近一半在职患者在成功进行经皮血管再通术后倾向于离职,而非在职患者很少因手术成功而被促使恢复工作。通常发现受过高等教育、生活在大城市的患者最常恢复原工作。