Jaeggi E T, Fasnacht M, Arbenz U, Beghetti M, Bauersfeld U, Friedli B
Paediatric Cardiology, University Children's Hospital of Geneva, 6 Rue Willy-Donzé, 1211, Geneva, Switzerland.
Int J Cardiol. 2001 Jun;79(1):71-6. doi: 10.1016/s0167-5273(01)00406-5.
Transcatheter coil occlusion of the patent ductus arteriosus (PDA) has become the interventional treatment option of choice. Immediate occlusion of any residual shunting results in excellent closure rates, but frequently requires multiple coil deployment.
To assess the efficacy and limitations of single Cook detachable coil PDA closure compared to a preceding series of Rashkind umbrella procedures.
Between 1990 and 1999, transcatheter occlusion of a small (<2 mm; n=45) or moderate-sized (2-4 mm; n=47) PDA was successfully attempted in 90/92 consecutive patients (mean age 6+/-4.8 years) with a coil (39/41) or Rashkind device (51/51). Immediate angiographic closure rates for both devices were low, although better for small (54-68%) than moderate ducts (7-22%, P<0.01). A 2-year echocardiographic closure rate of small ducts increased to 92% for the coil group versus 95% for the Rashkind group. By that time, moderate-sized ducts were only occluded in 64% with the coil and 54% with the Rashkind device. A visible residual shunt at post-implant angiography in moderate ducts was associated with a high incidence (59%) of long-term echocardiographic shunt patency and a need for repeat interventions for audible residual shunts (32%).
Single coil transcatheter occlusion is the treatment of choice for the small duct as most residual shunts will resolve spontaneously. However, long-term shunt persistence after single coil deployment in moderate sized ducts is as frequent as with the Rashkind device. A primary multiple coil approach is advocated if the postcoil aortogram shows residual ductal shunting and if there is persistence of a ductal murmur on auscultation.
经导管弹簧圈封堵动脉导管未闭(PDA)已成为首选的介入治疗方法。立即封堵任何残余分流可获得极高的闭合率,但通常需要多次放置弹簧圈。
与之前一系列Rashkind伞封堵术相比,评估使用单个Cook可脱卸弹簧圈封堵PDA的疗效和局限性。
1990年至1999年期间,对90/92例连续患者(平均年龄6±4.8岁)成功尝试经导管封堵小型(<2mm;n = 45)或中型(2 - 4mm;n = 47)PDA,分别使用弹簧圈(39/41)或Rashkind装置(51/51)。两种装置的即刻血管造影闭合率均较低,不过小型导管的闭合率(54 - 68%)优于中型导管(7 - 22%,P<0.01)。弹簧圈组小型导管的2年超声心动图闭合率升至92%,而Rashkind组为95%。到那时,中型导管使用弹簧圈的封堵率仅为64%,使用Rashkind装置的封堵率为54%。中型导管植入后血管造影可见残余分流与长期超声心动图分流通畅的高发生率(59%)以及因可闻及残余分流而需要重复干预的情况(32%)相关。
单弹簧圈经导管封堵是小型导管的首选治疗方法,因为大多数残余分流会自发消失。然而,在中型导管中单次放置弹簧圈后长期分流持续存在的情况与使用Rashkind装置时一样常见。如果弹簧圈置入后主动脉造影显示有残余导管分流且听诊时有导管杂音持续存在,则提倡采用初次多弹簧圈方法。