作为神经营养因子受体的独特性。

The uniqueness of being a neurotrophin receptor.

作者信息

Lee F S, Kim A H, Khursigara G, Chao M V

机构信息

Weill Medical College of Cornell University Medical College, New York, New York 10021, USA.

出版信息

Curr Opin Neurobiol. 2001 Jun;11(3):281-6. doi: 10.1016/s0959-4388(00)00209-9.

DOI:10.1016/s0959-4388(00)00209-9

PMID:11399425

Abstract

Neurotrophins rely on Trk tyrosine kinase and p75 receptors for signal transduction. Recently, other roles for these receptors have been identified. Many questions have been raised about the mechanism by which these receptors mediate diverse cellular functions. Studies indicate a great deal of neurotrophin signaling specificity may stem from ligand-receptor selectivity and intracellular protein recruitment.

摘要

神经营养因子依靠Trk酪氨酸激酶和p75受体进行信号转导。最近，已确定了这些受体的其他作用。关于这些受体介导多种细胞功能的机制，人们提出了许多问题。研究表明，大量的神经营养因子信号特异性可能源于配体-受体选择性和细胞内蛋白募集。