Trevisan M, Schisterman E, Mennotti A, Farchi G, Conti S
Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY 14214, USA.
Ann Epidemiol. 2001 Jul;11(5):312-9. doi: 10.1016/s1047-2797(00)00183-6.
To analyze the relationship between an aspect of drinking pattern (i.e., drinking with or without meals) and risk of all-cause and specific-cause mortality.
The Risk Factors and Life Expectancy Study, is a pooling of a series of epidemiological studies conducted in Italy. Eight-thousand six-hundred and forty-seven men and 6521 women, age 30-59 at baseline, and free of cardiovascular disease, were followed for mortality from all causes, cardiovascular and noncardiovascular, during an average follow-up of 7 years.
Drinkers of wine outside meals exhibited higher death rates from all causes, noncardiovascular diseases, and cancer, as compared to drinkers of wine with meals. This association was independent from the cardiovascular disease (CVD) risk factors measured at baseline and the amount of alcohol consumed and seemed to be stronger in women as compared to men.
The present results indicate that drinking patterns may have important health implications, and attention should be given to this aspect of alcohol use and its relationship to health outcomes. The relationship between alcohol consumption and disease has been the focus of intensive scientific investigation (1-9). Most studies to date, however, have limitations. A major drawback is that limited information has been collected regarding the complex issue of alcohol consumption. In many studies, ascertainment of alcohol consumption frequently focused only on quantity of alcohol consumed without considering the many different components of alcohol consumption, particularly drinking pattern (10-12). It has been hypothesized, and preliminary data support the notion, that drinking pattern could have important influences on determining the health effects of alcohol (13,14). The present study examines the relationship between one aspect of drinking pattern (drinking wine outside meals) and mortality in a large cohort of men and women.
分析饮酒模式的一个方面（即就餐时饮酒与否）与全因死亡率和特定病因死亡率之间的关系。
危险因素与预期寿命研究，是对在意大利开展的一系列流行病学研究的汇总分析。纳入了8647名男性和6521名女性，基线年龄为30 - 59岁，且无心血管疾病，在平均7年的随访期间，对其全因、心血管和非心血管疾病死亡率进行随访。
与就餐时饮酒者相比，就餐外饮酒者的全因、非心血管疾病和癌症死亡率更高。这种关联独立于基线时测量的心血管疾病（CVD）危险因素以及饮酒量，并且在女性中似乎比男性更强。
目前的结果表明，饮酒模式可能对健康有重要影响，应关注饮酒的这一方面及其与健康结果的关系。饮酒与疾病之间的关系一直是深入科学研究的重点（1 - 9）。然而，迄今为止的大多数研究都存在局限性。一个主要缺点是，关于饮酒这一复杂问题收集的信息有限。在许多研究中，饮酒量的确定往往只关注饮酒的数量，而没有考虑饮酒的许多不同组成部分，特别是饮酒模式（10 - 12）。据推测，并且初步数据支持这一观点，即饮酒模式可能对确定酒精对健康的影响有重要影响（13,14）。本研究考察了饮酒模式的一个方面（就餐外饮用葡萄酒）与一大群男性和女性死亡率之间的关系。
