Whiting D A
University of Texas Southwestern Medical Center, Dallas, TX 75246, USA.
Eur J Dermatol. 2001 Jul-Aug;11(4):332-4.
Finasteride is a type 2 5a-reductase inhibitor and therefore mimics the biochemical profile of inherited type 2 5a-reductase deficiency in men. It was developed to grow hair in androgenetic alopecia and shrink benign prostatic hyperplasia. Various clinical trials of finasteride have confirmed its beneficial effects in androgenetic alopecia in males, but not in females. It can produce visible hair growth in up to 66% of men with mild to moderate alopecia, but importantly can stop hair loss in 91% of patients. In long-term finasteride studies, placebo patients were characterized by significant and progressive hair loss. It can be concluded that finasteride prevents further hair loss by actually continuing to grow enough hair to preserve scalp coverage. This is confirmed by the loss of hair following withdrawal of finasteride in such cases. The proven preservative effect of finasteride, in addition to its restorative effect, is a strong indication for prescribing it in early cases of androgenetic alopecia before much hair has been lost.
非那雄胺是一种2型5α-还原酶抑制剂，因此模拟了男性遗传性2型5α-还原酶缺乏的生化特征。它被开发用于治疗雄激素性脱发和缩小良性前列腺增生。非那雄胺的各种临床试验已证实其对男性雄激素性脱发有有益作用，但对女性无效。它能使高达66%的轻度至中度脱发男性长出可见的头发，但重要的是能使91%的患者停止脱发。在非那雄胺的长期研究中，安慰剂组患者的特征是出现显著且进行性的脱发。可以得出结论，非那雄胺通过持续长出足够的头发以保持头皮覆盖来防止进一步脱发。在这种情况下，停用非那雄胺后出现脱发证实了这一点。非那雄胺已证实的防止脱发效果，除了其恢复作用外，是在雄激素性脱发早期且脱发不多时就开此药的有力指征。
