Singh N, Rajya B S, Mohanty G C
Cornell Vet. 1975 Jul;65(3):363-73.
Granular vulvovaginitis (GVV) was experimentally produced in female kids by topical application of M. agalactiae on the scarified vulvar mucosa. Grossly visible GVV lesions were seen in 25 out of 30 infected kids, yet all were positive for microscopic lesions. Microscope lesions that appeared by 7 days post infection (DPI) were comprised of stromal oedema, lymphocytic infiltration into the lamina propria and perivascular accumulation of a few lymphocytes. The lesions observed between 28 and 49 DPI were comparable to those of spontaneous cases (severe). The changes seen in kids euthanized between 56 to 70 DPI were suggestive of the chronic stage of the disease. M. agalactiae was reisolated from all the infected kids from 7 to 70 days after inoculation. The pathology and pathogenesis of this condition have been described and discussed.
通过在划破的外阴黏膜上局部涂抹无乳链球菌，在雌性幼羊身上实验性地诱发了颗粒性外阴阴道炎（GVV）。在30只受感染的幼羊中，有25只出现了肉眼可见的GVV病变，但所有幼羊的微观病变均呈阳性。感染后7天（DPI）出现的微观病变包括基质水肿、淋巴细胞浸润至固有层以及少量淋巴细胞的血管周围聚集。在28至49 DPI观察到的病变与自然病例（严重）的病变相当。在56至70 DPI实施安乐死的幼羊身上看到的变化提示了该疾病的慢性阶段。在接种后7至70天，从所有受感染的幼羊中再次分离出无乳链球菌。已对这种病症的病理学和发病机制进行了描述和讨论。
