Byg KELD-ERIK, Milman NILS, Ole Agger ANDERS
Department of Medicine, Naestved Hospital, Naestved, and Department of Obstetrics, Herning Hospital, Herning, Denmark.
Hematology. 2000;4(6):529-539.
The aim was to evaluate relationships between iron status markers (haemoglobin, erythrocyte indices, serum iron, serum transferrin, serum transferrin saturation, serum ferritin) in normal pregnancy. Iron status markers were measured at 4-week-intervals during pregnancy and postpartum in 120 healthy women; 62 had daily treatment with tablets containing 66 mg ferrous iron, 58 were treated with placebo. Placebo-treated: Ferritin displayed positive correlations with transferrin saturation during 2nd and 3rd trimester. There were positive correlations between ferritin, erythrocyte MCV and MCH during 2nd and 3rd trimester and postpartum. Prior to delivery and postpartum, ferritin demonstrated positive correlations with haemoglobin. Transferrin saturation showed positive correlations with MCV, MCH and MCHC during 2nd and 3rd trimester and postpartum. Transferrin saturation displayed positive correlations with haemoglobin prior to delivery and postpartum. Iron-treated: In general, there were no correlations between iron status markers. Positive correlations appeared postpartum between ferritin, transferrin saturation and MCHC but not with haemoglobin. Transferrin saturation showed a positive correlation with MCH postpartum, but not with haemoglobin. Conclusion: The patterns of relationships in placebo-treated women were consistent with iron deficient erythropoiesis.
目的是评估正常妊娠中铁状态标志物（血红蛋白、红细胞指数、血清铁、血清转铁蛋白、血清转铁蛋白饱和度、血清铁蛋白）之间的关系。对120名健康女性在孕期和产后每隔4周测量一次铁状态标志物；62名每日服用含66毫克亚铁的片剂，58名服用安慰剂。服用安慰剂组：在妊娠中期和晚期，铁蛋白与转铁蛋白饱和度呈正相关。在妊娠中期和晚期以及产后，铁蛋白、红细胞平均体积（MCV）和平均红细胞血红蛋白含量（MCH）之间呈正相关。在分娩前和产后，铁蛋白与血红蛋白呈正相关。在妊娠中期和晚期以及产后，转铁蛋白饱和度与MCV、MCH和平均红细胞血红蛋白浓度（MCHC）呈正相关。在分娩前和产后，转铁蛋白饱和度与血红蛋白呈正相关。服用铁剂组：一般来说，铁状态标志物之间无相关性。产后铁蛋白、转铁蛋白饱和度和MCHC之间出现正相关，但与血红蛋白无关。产后转铁蛋白饱和度与MCH呈正相关，但与血红蛋白无关。结论：服用安慰剂女性的关系模式与缺铁性红细胞生成一致。
