Kandeel F R, Koussa V K, Swerdloff R S
The Leslie and Susan Gonda (Goldschmied) Diabetes and Genetic Research Center, Department of Diabetes, Endocrinology & Metabolism, City of Hope National Medical Center, Duarte, California 91010, USA. fkandeel.coh.org
Endocr Rev. 2001 Jun;22(3):342-88. doi: 10.1210/edrv.22.3.0430.
This review is designed to help the reproductive endocrinologist integrate his or her professional activity with those of other disciplines including urology, radiology, neurology, and psychology in order to successfully manage all of the inseparable aspects of male sexual and reproductive functioning. Significant advances in the field of male sexual physiology and pathophysiology and new methods of investigation and treatment of male sexual disorders are outlined. The review synthesizes available data on the following: norms of sexual organs, aging and sexuality, role of central and peripheral neurochemicals in each stage of the sexual cycle, role of corporeal smooth muscles in the hemodynamic control of erection and detumescence, influence of psychological factors, drugs, and disease on all aspects of sexual functioning, and use of nocturnal penile tumescence monitoring, imaging investigations, and neurophysiologic studies in the diagnostic workup of males with sexual dysfunction. Clinical algorithms are presented where appropriate. Extensive discussions on newly developed strategies in psychological and behavioral counseling, drug therapy, tissue engineering, nonsurgical devices, and surgical treatments for all forms of sexual disorders are also provided. Lastly, the effect of sexual dysfunction and its treatment on quality of life in affected men is addressed, along with recommendations for future research endeavors.
本综述旨在帮助生殖内分泌学家将其专业活动与包括泌尿外科、放射科、神经科和心理学在内的其他学科的活动相结合，以便成功管理男性性与生殖功能中所有不可分割的方面。文中概述了男性性生理学和病理生理学领域的重大进展以及男性性功能障碍的新调查和治疗方法。该综述综合了以下方面的现有数据：性器官的标准、衰老与性、中枢和外周神经化学物质在性周期各阶段的作用、阴茎海绵体平滑肌在勃起和消肿血流动力学控制中的作用、心理因素、药物和疾病对性功能各方面的影响，以及夜间阴茎勃起监测、影像学检查和神经生理学研究在男性性功能障碍诊断检查中的应用。在适当的地方给出了临床算法。还对心理和行为咨询、药物治疗、组织工程、非手术器械以及针对各种形式性功能障碍的手术治疗等新制定的策略进行了广泛讨论。最后，探讨了性功能障碍及其治疗对受影响男性生活质量的影响，并提出了未来研究工作的建议。
