[注意力缺陷多动障碍中位于Xp11的易感基因座研究]
[Study of susceptibility loci located within Xp11 in attention deficit hyperactivity disorder].
作者信息
Jiang S, Xin R, Qian Y, Lin S, Li F, Wu X, Wang D, Tang G, Jiang K
机构信息
Shanghai Mental Health Center, Shanghai 200030 P. R. China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001 Jun;18(3):169-72.
OBJECTIVE
To detect the genetic relationship between monoamine oxidase(MAO) A type gene and attention deficit hyperactivity disorder(ADHD) in Chinese.
METHODS
The haplotype-based haplotype relative risk(HHRR) and the transmission disequilibrium test(TDT) methods were used to analyze the genetic association and linkage in 60 ADHD children and their parents.
RESULTS
In this sample were found significant association (chi(2)=4.90, P<0.05) and linkage (chi(2)=4.84, P<0.05) between the MAOCA 114bp allele and DSM-III-R-diagnosed ADHD in trios composed of father, mother and affected offspring.
CONCLUSION
The above results suggested that ADHD was associated and in linkage with MAO A gene, and the susceptibility loci might reside in chromosome Xp11 for ADHD.
目的
检测中国人群中，单胺氧化酶（MAO）A 型基因与注意力缺陷多动障碍（ADHD）之间的遗传关系。
方法
采用基于单倍型的单倍型相对风险（HHRR）和传递不平衡检验（TDT）方法，对60名ADHD儿童及其父母进行遗传关联和连锁分析。
结果
在由父亲、母亲和患病后代组成的三联体中，发现MAOCA 114bp等位基因与DSM-III-R诊断的ADHD之间存在显著关联（χ²=4.90，P<0.05）和连锁（χ²=4.84，P<0.05）。
结论
上述结果表明，ADHD与MAO A基因存在关联和连锁，ADHD的易感位点可能位于Xp11染色体上。
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