Gao Qian, Liu Lu, Qian Qiujin, Wang Yufeng
Peking University Sixth Hospital Institute of Mental Health, Beijing, China ; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China.
Shanghai Arch Psychiatry. 2014 Aug;26(4):194-206. doi: 10.3969/j.issn.1002-0829.2014.04.003.
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition in children worldwide that typically includes a combination of symptoms of inattention and hyperactivity/impulsivity. Genetic factors are believed to be important in the development and course of ADHD so many candidate genes studies and genome-wide association studies (GWAS) have been conducted in search of the genetic mechanisms that cause or influence the condition. This review provides an overview of gene association and pharmacogenetic studies of ADHD from mainland China and elsewhere that use Han Chinese samples. To date, studies from China and elsewhere remain inconclusive so future studies need to consider alternative analytic techniques and test new biological hypotheses about the relationship of neurotransmission and neurodevelopment to the onset and course of this disabling condition.
注意缺陷多动障碍（ADHD）是一种在全球儿童中常见的精神疾病，通常包括注意力不集中和多动/冲动症状的组合。遗传因素被认为在ADHD的发生发展过程中起着重要作用，因此已经开展了许多候选基因研究和全基因组关联研究（GWAS），以寻找导致或影响该疾病的遗传机制。本综述概述了来自中国大陆及其他地区使用汉族样本的ADHD基因关联研究和药物遗传学研究。迄今为止，来自中国和其他地区的研究仍无定论，因此未来的研究需要考虑采用替代分析技术，并检验关于神经传递和神经发育与这种致残性疾病的发病及病程关系的新生物学假说。
