Khan W A, Attal H, Vernick J, Bedrossian C W
Department of Pathology, William Beaumont Hospital, Royal Oak, MI, USA.
Semin Diagn Pathol. 2001 May;18(2):104-9.
A case of primary leptomeningeal fibrosarcoma metastatic to the thyroid gland, diagnosed by fine needle aspiration biopsy is described. The patient, a 39-year-old women was initially diagnosed with a leptomeningeal fibrosarcoma. Sections of the primary tumor studied by electron microscopy showed that the tumor cells have the ultrastructure features of a fibroblast. She underwent tumor resection, followed by chemotherapy and local radiotherapy. Four months later, she presented with dysphagia. Ultrasonography confirmed the presence of a 2-cm mass in the right lobe of thyroid. A fine needle aspiration biopsy was performed. Light microscopy showed interwoven bundles of neoplastic spindle cells similar to the primary tumor, consistent with a metastatic fibrosarcoma. To our knowledge, this is the first report of a primary meningeal fibrosarcoma that metastasized to the thyroid gland, which was diagnosed by a fine needle aspiration biopsy.
本文描述了一例通过细针穿刺活检诊断为原发性软脑膜纤维肉瘤转移至甲状腺的病例。患者为一名39岁女性，最初被诊断为软脑膜纤维肉瘤。通过电子显微镜研究的原发性肿瘤切片显示，肿瘤细胞具有成纤维细胞的超微结构特征。她接受了肿瘤切除术，随后进行了化疗和局部放疗。四个月后，她出现吞咽困难。超声检查证实甲状腺右叶有一个2厘米的肿块。进行了细针穿刺活检。光学显微镜检查显示，肿瘤性梭形细胞交织成束，与原发性肿瘤相似，符合转移性纤维肉瘤。据我们所知，这是首例通过细针穿刺活检诊断为转移至甲状腺的原发性脑膜纤维肉瘤的报告。
