Chakraborty P, Shrivastava G C
Experientia. 1975 Jul 15;31(7):850-2. doi: 10.1007/BF01938501.
Three known antitumour drugs have been tested for their effect on the GAT/GNase ratio of Ehrlich Ascites cells and host plasma. It was observed that all these drugs had changed the ratio of the 2 types of glutaminases from below 1.0 to the normal value of 1.0, this was accompanied with an increase in the survival time of the tumour-bearing animals. There was, however, no effect on the plasma GAT/GNase ratio of normal animals in the presence of the 3 antitumour compounds tested.
已对三种已知的抗肿瘤药物对艾氏腹水癌细胞和宿主血浆的谷氨酰胺转移酶/谷氨酰胺酶（GAT/GNase）比率的影响进行了测试。观察到所有这些药物都使两种谷氨酰胺酶的比率从低于1.0变为正常的1.0，这伴随着荷瘤动物存活时间的延长。然而，在所测试的三种抗肿瘤化合物存在的情况下，对正常动物的血浆GAT/GNase比率没有影响。
