von Heimburg D, Pallua N
Department of Plastic Surgery, University Hospital, Aachen University of Technology, Germany.
Ann Plast Surg. 2001 Jun;46(6):644-6. doi: 10.1097/00000637-200106000-00014.
Although there are numerous clinical reports relating to the injection of adipose tissue fragments, only few histological assessments of the histology of these grafts in late follow-up have been made. The authors report a case of adipose tissue harvested with a sharp cannula using low-pressure suction and injection in the lower eyelid areas with subsequent sagging of the graft, although maintenance of volume, after 2 years. The operative corrective procedure consisted of a lower blepharoplasty and removal of the sheathed graft. Histology showed extended oil cysts and a surrounding capsulelike structure. The volume of the graft consisted mainly of oil cysts, and not healthy adipose tissue. The conclusion is that the harvesting procedure damages fragile adipocytes. The outcome of adipose tissue injection thus remains unpredictable. The only reliable guarantee for a good long-term outcome after lipofilling is a specimen biopsy showing healthy adipose tissue.
尽管有大量关于注射脂肪组织碎片的临床报告，但对这些移植组织后期组织学的评估却很少。作者报告了一例使用尖锐套管以低压抽吸方式获取脂肪组织，并在下眼睑区域进行注射，两年后移植组织出现下垂，尽管仍维持了一定体积。手术矫正程序包括下睑成形术和去除带鞘的移植组织。组织学检查显示有扩大的油囊肿和周围的囊状结构。移植组织的体积主要由油囊肿组成，而非健康的脂肪组织。结论是采集过程会损害脆弱的脂肪细胞。因此，脂肪组织注射的结果仍然不可预测。脂肪填充后长期良好效果的唯一可靠保证是活检标本显示为健康的脂肪组织。
