Syntheses of two deacetyl-thymosin beta4 analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw.
作者信息
Abiko T, Ogawa R
机构信息
Research Laboratory, Global Shinwa Pharmaceutical Co. Ltd., Iwate-ken, Japan.
出版信息
Mediators Inflamm. 2001 Apr;10(2):89-92. doi: 10.1080/09629350120054563.
Abstract
Two [Met(0)6]deacetyl-thymosin beta4 analogs containing Phe(4F) or Tyr(Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied. Fluorination of the para-position of Phe12 resulted in a marked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our synthetic [Met(0)6]deacetyl-thymosin beta4, but the other analog, [Met(0)6, Tyr(Me)12]deacetyl-thymosin beta4, showed a marked reduction of the anti-inflammatory effect.
摘要
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本文引用的文献
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Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids.
Nat Med. 1999 Dec;5(12):1424-7. doi: 10.1038/71002.
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