直面交锋——激活型与抑制型免疫受体之间的相互作用
Face off--the interplay between activating and inhibitory immune receptors.
作者信息
Lanier L L
机构信息
Department of Microbiology and Immunology and the Cancer Research Institute, University of California (San Francisco), 513 Parnassus Avenue, Box 0414, 94143-0414, San Francisco, CA, USA.
出版信息
Curr Opin Immunol. 2001 Jun;13(3):326-31. doi: 10.1016/s0952-7915(00)00222-3.
Abstract
The function of leukocytes is regulated by the integration of positive and negative signals received through cell surface receptors. Related receptors with similar extracellular domains and often binding the same ligands can transmit either inhibitory or activating signals. Studies are beginning to reveal how these 'paired receptors' control immune functions.
摘要
白细胞的功能是通过整合细胞表面受体接收到的正负信号来调节的。具有相似细胞外结构域且通常结合相同配体的相关受体可以传递抑制性或激活性信号。研究开始揭示这些“配对受体”如何控制免疫功能。
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