通过钙调神经磷酸酶/糖原合酶激酶-3对活化T细胞核因子（NF-AT）核穿梭的控制来监测抗原受体占据的持续时间。
Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling.
作者信息
Neilson J, Stankunas K, Crabtree G R
机构信息
Department of Microbiology and Immunology, Stanford University Medical School, 279 Campus Drive, 94305, Stanford, CA, USA.
出版信息
Curr Opin Immunol. 2001 Jun;13(3):346-50. doi: 10.1016/s0952-7915(00)00225-9.
Abstract
Recent structural studies have supported a kinetic model of TCR activation, raising the question of how the duration of receptor occupancy is translated into activation of immune response genes. We summarize evidence that the cytoplasmic-to-nuclear shuttling of NF-ATc family members monitors the duration of receptor occupancy.
摘要
最近的结构研究支持了TCR激活的动力学模型，这就提出了一个问题，即受体占据的持续时间是如何转化为免疫反应基因的激活的。我们总结了证据表明NF-ATc家族成员的胞质到核穿梭监测受体占据的持续时间。
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