通过碱基脱氨作用进行的RNA编辑：更多的酶、更多的靶点、新的谜团。

RNA editing by base deamination: more enzymes, more targets, new mysteries.

作者信息

Gerber A P, Keller W

机构信息

Dept of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

出版信息

Trends Biochem Sci. 2001 Jun;26(6):376-84. doi: 10.1016/s0968-0004(01)01827-8.

DOI:10.1016/s0968-0004(01)01827-8

PMID:11406411

Abstract

The posttranscriptional modification of messenger RNA precursors (pre-mRNAs) by base deamination can profoundly alter the physiological function of the encoded proteins. The recent identification of tRNA-specific adenosine deaminases (ADATs) has led to the suggestion that these enzymes, as well as the cytidine and adenosine deaminases acting on pre-mRNAs (CDARs and ADARs), belong to a superfamily of RNA-dependent deaminases. This superfamily might have evolved from an ancient cytidine deaminase. This article reviews the reactions catalysed by these enzymes and discusses their evolutionary relationships.

摘要

信使核糖核酸前体（前体mRNA）通过碱基脱氨进行的转录后修饰可深刻改变所编码蛋白质的生理功能。最近对tRNA特异性腺苷脱氨酶（ADAT）的鉴定表明，这些酶以及作用于前体mRNA的胞苷脱氨酶和腺苷脱氨酶（CDAR和ADAR）属于RNA依赖性脱氨酶超家族。这个超家族可能是从一种古老的胞苷脱氨酶进化而来的。本文综述了这些酶催化的反应，并讨论了它们的进化关系。