Gude T, Vaglum P
Faculty of Medicine, Department of Behavioural Sciences in Medicine, University of Oslo, N-0317 Oslo, Norway.
J Pers Disord. 2001 Jun;15(3):216-28. doi: 10.1521/pedi.15.3.216.19210.
This one-year, post-treatment prospective study of consecutively admitted patients to a national psychiatric in-patient clinic, compares patients belonging to four subgroups of DSM-III-R personality disorder (PDs): "pure cluster A (N = 21), "pure" B (N = 67), "pure" C (N = 251), and Axis II "comorbid" C (N = 138). Outcome was measured by SCl-90 and occupational status. Axis I disorders were controlled for in all analyses. Contrary to our hypothesis, patients in pure cluster C had no better outcome than either Axis II comorbid cluster C patients or patients with pure cluster A or B. Although pure C patients relapsed in symptom distress after discharge, comorbid C patients did not. C patients with an additional Histrionic PD were less at risk to be a case at follow up (GSI level > 1.00). Cluster C disorders as a whole had negative impact upon outcome in the total sample. These findings suggest the need for better treatment of patients with cluster C conditions.
这项针对一家国家级精神科住院诊所连续收治患者的为期一年的治疗后前瞻性研究，比较了属于《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）人格障碍（PDs）四个亚组的患者：“单纯A组”（N = 21）、“单纯”B组（N = 67）、“单纯”C组（N = 251）以及轴II“共病”C组（N = 138）。通过症状自评量表90（SCl-90）和职业状况来衡量结果。在所有分析中都对轴I障碍进行了控制。与我们的假设相反，单纯C组患者的结局并不比轴II共病C组患者或单纯A组或B组患者更好。尽管单纯C组患者出院后症状困扰复发，但共病C组患者没有。伴有另外表演型人格障碍的C组患者在随访时成为病例（全球严重程度指数水平> 1.00）的风险较低。总体而言，C组障碍对整个样本的结局有负面影响。这些发现表明需要更好地治疗患有C组疾病的患者。
