四种新型三唑类药物对拟青霉属真菌的体外活性
In vitro activities of four novel triazoles against Scedosporium spp.
作者信息
Carrillo A J, Guarro J
机构信息
Department of Microbiology, Asesoría Científica y de Investigación Aplicada, 08037 Barcelona, Spain.
出版信息
Antimicrob Agents Chemother. 2001 Jul;45(7):2151-3. doi: 10.1128/AAC.45.7.2151-2153.2001.
Abstract
In order to develop new approaches to the treatment of the severe and usually fatal infections caused by Scedosporium spp., the in vitro antifungal activities of four novel triazoles (posaconazole, ravuconazole, voriconazole, and UR-9825) and some current antifungals (amphotericin B, ketoconazole, itraconazole, and nystatin) were determined. The latter group was clearly ineffective against the two species tested. The four new antifungals showed activity against Scedosporium apiospermum, and UR-9825 and voriconazole were active against S. prolificans.
摘要
为开发治疗由赛多孢属真菌引起的严重且通常致命感染的新方法，测定了四种新型三唑类药物（泊沙康唑、雷夫康唑、伏立康唑和UR - 9825）以及一些现有抗真菌药物（两性霉素B、酮康唑、伊曲康唑和制霉菌素）的体外抗真菌活性。后一组药物对所测试的两种真菌明显无效。这四种新型抗真菌药物对尖端赛多孢有活性，UR - 9825和伏立康唑对多育赛多孢有活性。
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