Taksey J, Craig T J
Pennsylvania State University, College of Medicine, Hershey, Pa., USA.
J Am Osteopath Assoc. 2001 May;101(5 Suppl):S4-7.
The frequency of sensitization to environmental antigens changes in different regions. As such, the pattern of sensitivity to common allergens was studied at multiple sites across central Pennsylvania, an area composed of small cities and rural communities, to determine uniqueness of allergies in populations from this area in contrast to allergies as determined by skin testing in large urban centers. The study reported was undertaken to determine allergen variation from an urban population compared with a rural population of a Northeastern state so that environmental avoidance and immunotherapy can be more precisely prescribed. Patient charts were retrospectively reviewed to determine sensitivity to house dust mites (Dermatophagoides pteronyssinus, Dermatophagoides farinae), cockroach, Penicillium, Aspergillus spp, dog, cat, timothy grass, ragweed, oak, and Alternaria tenuis at five sites in Pennsylvania. All of these sites were classified as "small city" or "rural" for the study. One hundred patient records were examined at each site for the results of allergy testing by the prick puncture, radioallergosorbent test (RAST), or intradermal methods. These small-city and rural data were pooled and compared with that of the National Cooperative Inner-City Asthma Study (NCI-CAS), which included 1286 patients from urban environments. The prevalence of allergy to both species of dust mites, dog, timothy grass, and ragweed was significantly greater in the pooled rural group than in the NCICAS inner-city patients (P < .05). In contrast, sensitivity to cockroach antigens and Alternaria was significantly greater in the NCICAS urban population than in the pooled rural group (P < .05). No statistically significant difference was found between the NCICAS and the pooled rural patients in reference to Penicillium, cat, and oak (P > .05).
对环境抗原的致敏频率在不同地区有所变化。因此，在宾夕法尼亚州中部的多个地点研究了对常见过敏原的敏感模式，该地区由小城市和农村社区组成，目的是确定该地区人群过敏的独特性，并与在大型城市中心通过皮肤试验确定的过敏情况进行对比。所报道的这项研究旨在确定与东北部一个州的农村人口相比，城市人口的过敏原差异，以便更精确地制定环境规避和免疫疗法。回顾性审查患者病历，以确定宾夕法尼亚州五个地点的患者对屋尘螨（粉尘螨、户尘螨）、蟑螂、青霉、曲霉属、狗、猫、梯牧草、豚草、橡树和链格孢的敏感性。在该研究中，所有这些地点都被归类为“小城市”或“农村”。在每个地点检查100份患者记录，以获取针刺试验、放射变应原吸附试验（RAST）或皮内试验的过敏测试结果。将这些小城市和农村的数据汇总，并与全国城市内哮喘合作研究（NCI - CAS）的数据进行比较，该研究包括1286名来自城市环境的患者。在汇总的农村组中，对两种尘螨、狗、梯牧草和豚草过敏的患病率显著高于NCI - CAS城市内患者（P < 0.05）。相比之下，NCI - CAS城市人口对蟑螂抗原和链格孢的敏感性显著高于汇总的农村组（P < 0.05）。在青霉、猫和橡树方面，NCI - CAS和汇总的农村患者之间未发现统计学上的显著差异（P > 0.05）。
