Ma Q P
Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, UK.
Neuroreport. 2001 Jun 13;12(8):1589-91. doi: 10.1097/00001756-200106130-00015.
Anti-migraine triptan drugs are 5-HT(1B/1D) receptor agonists which are thought to block the neurotransmitter/neuropeptide release from sensory nerve terminals and directly constrict blood vessel smooth muscles. In the present study, we have investigated the anatomical basis for a possible modulation of glutamate release from trigeminal ganglion neurons by 5-HT(1B/1D) receptor agonists and by 5-HT1F receptor agonists, using double immunohistochemical staining technique in the rat. The majority of 5-HT1B, 5-HT1D or 5-HT1F receptor positive neurons were also glutamate positive, but both 5-HT1B, 5-HT1D or 5-HT1F receptor single-labeled and glutamate single-labeled neurons were observed. These results suggest that 5-HT(1B/1D/1F) receptor agonists may modulate glutamate release, and that one mechanism of their anti-migraine action could be the blockade of glutamate release.
抗偏头痛曲坦类药物是5-羟色胺(1B/1D)受体激动剂,被认为可阻断感觉神经末梢释放神经递质/神经肽,并直接收缩血管平滑肌。在本研究中,我们利用大鼠双重免疫组织化学染色技术,研究了5-羟色胺(1B/1D)受体激动剂和5-羟色胺1F受体激动剂对三叉神经节神经元谷氨酸释放进行可能调节的解剖学基础。大多数5-羟色胺1B、5-羟色胺1D或5-羟色胺1F受体阳性神经元也是谷氨酸阳性,但也观察到了5-羟色胺1B、5-羟色胺1D或5-羟色胺1F受体单标记神经元和谷氨酸单标记神经元。这些结果表明,5-羟色胺(1B/1D/1F)受体激动剂可能调节谷氨酸释放,其抗偏头痛作用的一种机制可能是阻断谷氨酸释放。