Frauscher F, Klauser A, Halpern E J, Horninger W, Bartsch G
Lancet. 2001 Jun 9;357(9271):1849-50. doi: 10.1016/s0140-6736(00)04970-9.
The diagnosis of prostate cancer is currently limited by the low sensitivity and specificity of systematic conventional grey-scale ultrasonography. We assessed contrast-enhanced colour Doppler ultrasonography by means of a microbubble ultrasound contrast agent to detect tumour vascularity and improve the diagnosis of prostate cancer. The use of a microbubble ultrasound contrast agent for transrectal colour Doppler targeted biopsy significantly improved the detection of prostate cancer compared with systematic biopsy following conventional grey-scale ultrasonography (p<0.001). Contrast-agent enhanced colour Doppler imaging may allow for limited targeted biopsies (five or less), which reduces costs and morbidity.
目前，前列腺癌的诊断受限于系统常规灰阶超声的低敏感性和特异性。我们通过一种微泡超声造影剂评估了超声造影增强彩色多普勒超声，以检测肿瘤血管并改善前列腺癌的诊断。与常规灰阶超声检查后的系统活检相比，使用微泡超声造影剂进行经直肠彩色多普勒靶向活检显著提高了前列腺癌的检出率（p<0.001）。造影剂增强彩色多普勒成像可能允许进行有限的靶向活检（五次或更少），这可降低成本和发病率。
