Woehlke G, Schliwa M
Adolf-Butenandt-Institut, Zellbiologie, University of Munich, Schillerstrasse 42, 80336 Munich, Germany.
Nat Rev Mol Cell Biol. 2000 Oct;1(1):50-8. doi: 10.1038/35036069.
The gallop of a race horse and the minute excursions of a cellular vesicle have one thing in common: they are based on the directional movement of proteins termed molecular motors -- many trillions in the case of the horse, just a few in the case of the cell vesicle. These tiny machines take nanometre steps on a millisecond timescale to drive all biological movements. Over the past 15 years new biochemical and biophysical approaches have allowed us to take a giant step forward in understanding the molecular basis of motor mechanics.
它们都基于被称为分子马达的蛋白质的定向运动——就马而言有无数个，而细胞囊泡只有几个。这些微小的机器在毫秒时间尺度上迈出纳米级的步伐，以驱动所有的生物运动。在过去15年里，新的生物化学和生物物理方法使我们在理解马达机制的分子基础方面向前迈出了一大步。
