Sarrecchia C, Niutta P, Testore G P, Sordillo P, Proietti F, Andreoni M
Dipartimento di Sanità Pubblica, Università Tor Vergata, Roma.
Recenti Prog Med. 2001 May;92(5):336-9.
The study describes the clinical, virologic and immunological characteristics of a patient with interstitial pulmonary fibrosis during interferon treatment for HCV chronic hepatitis. After the interruption of the interferon and the beginning of immunosuppressive treatment, an improvement of pulmonary pathology was observed. At the reintroduction of interferon, the patient presented a rapid worsening of pulmonary fibrosis with a normalization of biochemical and virologic parameters of hepatitis. The correlation among interstitial pulmonary fibrosis, HCV infection and interferon treatment is discussed; however in the described case, the pulmonary pathology was correlated to interferon treatment.
该研究描述了一名间质性肺纤维化患者在接受干扰素治疗慢性丙型肝炎期间的临床、病毒学和免疫学特征。在中断干扰素治疗并开始免疫抑制治疗后，观察到肺部病理状况有所改善。再次引入干扰素后，患者肺部纤维化迅速恶化，而肝炎的生化和病毒学参数恢复正常。文中讨论了间质性肺纤维化、丙型肝炎病毒感染与干扰素治疗之间的相关性；然而，在所描述的病例中，肺部病理状况与干扰素治疗相关。
