Mennerick S, Zorumski C F
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mol Neurobiol. 2000 Aug-Dec;22(1-3):41-54. doi: 10.1385/MN:22:1-3:041.
Recent evidence suggests that blockade of normal excitation in the immature nervous system may have profound effects on neuronal survival during the period of natural cell death. Cell loss following depression of electrical activity in the central nervous system (CNS) may explain the neuropsychiatric deficits in humans exposed to alcohol or other CNS depressants during development. Thus, understanding the role of electrical activity in the survival of young neurons is an important goal of modern basic and clinical neuroscience. Here we review the evidence from in vivo and in vitro model systems that electrical activity participates in promoting neuronal survival. We discuss the potential role of moderate elevations of intracellular calcium in promoting survival, and we address the possible ways in which activity and conventional trophic factors may interact.
最近的证据表明，在自然细胞死亡期间，阻断未成熟神经系统中的正常兴奋可能对神经元存活产生深远影响。中枢神经系统（CNS）电活动抑制后的细胞丢失可能解释了在发育过程中接触酒精或其他中枢神经系统抑制剂的人类所出现的神经精神缺陷。因此，了解电活动在年轻神经元存活中的作用是现代基础和临床神经科学的一个重要目标。在这里，我们回顾了来自体内和体外模型系统的证据，即电活动参与促进神经元存活。我们讨论了细胞内钙适度升高在促进存活中的潜在作用，并探讨了活动与传统营养因子可能相互作用的可能方式。
