Petty H R
Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Immunol Res. 2001;23(1):85-94. doi: 10.1385/IR:23:1:85.
Neutrophil activation is an essential event in inflammatory responses. How cells coordinate, integrate, manage, and distribute information on physiologically-relevant timescales are not well understood. Although neutrophil oscillators have been known for many years, their biological roles have not been identified. We suggest that intracellular oscillators (such as NAD(P)H, pH, calcium, and so on) account for functional oscillations (e.g., superoxide and NO production, cytolytic marker release, pericellular proteolysis, and actin assembly). In addition to these well-known temporal oscillations, we have recently discovered self-organized traveling chemical waves in neutrophils; these waves respond to extracellular signals and have distinct origins that coincide with a cell's uropod, lamellipodium, or adherence site. The fundamental physico-chemical features of cell chemistry will have an increasing role in our understanding of leukocyte function.
中性粒细胞活化是炎症反应中的一个重要事件。细胞如何在生理相关的时间尺度上协调、整合、管理和分配信息，目前还不太清楚。尽管中性粒细胞振荡器已为人所知多年，但其生物学作用尚未明确。我们认为，细胞内振荡器（如NAD(P)H、pH、钙等）导致了功能振荡（如超氧化物和一氧化氮的产生、溶细胞标志物的释放、细胞周围蛋白水解和肌动蛋白组装）。除了这些众所周知的时间振荡外，我们最近还在中性粒细胞中发现了自组织传播化学波；这些波对细胞外信号作出反应，并且有与细胞的尾足、片状伪足或粘附位点一致的不同起源。细胞化学的基本物理化学特征在我们对白细胞功能的理解中将发挥越来越重要的作用。
