编码III型分泌系统的沙门氏菌致病岛

Salmonella pathogenicity islands encoding type III secretion systems.

作者信息

Hansen-Wester I, Hensel M

机构信息

Lehrstuhl für Bakteriologie, Max von Pettenkofer-Institut, LMU München, Germany.

出版信息

Microbes Infect. 2001 Jun;3(7):549-59. doi: 10.1016/s1286-4579(01)01411-3.

DOI:10.1016/s1286-4579(01)01411-3

PMID:11418329

Abstract

Salmonella enterica harbours two Salmonella pathogenicity islands (SPIs) each encoding a type III secretion system for virulence proteins. SPI1 is required for invasion, while systemic infections and intracellular accumulation of Salmonella are dependent on SPI2 function. This review will describe and compare the genetic organisation, evolution, regulation and molecular functions of SPI1 and SPI2.

摘要

肠炎沙门氏菌含有两个沙门氏菌致病岛（SPIs），每个致病岛都编码一个用于分泌毒力蛋白的III型分泌系统。SPI1是侵袭所必需的，而沙门氏菌的全身感染和细胞内积累则依赖于SPI2的功能。本综述将描述并比较SPI1和SPI2的基因组织、进化、调控及分子功能。