从人类、家禽和海鲜中分离出的毒力编码基因的保守性 。
Virulence-Encoding Genes Conserved in Isolated From Humans, Poultry, and Seafood.
作者信息
Adesiji Yemisi Olukemi, Deekshit Vijaya Kumar, Odunola Rasheed A, Karunasagar Indrani, Daodu Oluwafemi B, Ahmad Al-Mustapha
机构信息
Department of Medical Microbiology and Parasitology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo, Nigeria.
Department of Microbiology, K. S. Hegde Medical Academy, Faculty of Allied Health Services, Nitte University, Deralakatte, Mangalore, India.
出版信息
J Trop Med. 2025 Jul 2;2025:1139253. doi: 10.1155/jotm/1139253. eCollection 2025.
Diverse virulence genes encode for the Type III secretion system (T3SS) in bacteria. In , these genes are located in the pathogenicity Islands 1 and 2 (SPI-1 and SPI-2), and they facilitate bacterial invasion and replication within macrophages, contributing to the burden of nontyphoidal infections. In this study, we investigated the prevalence of selected virulence-encoding genes in 30 laboratory stocks of from Nigeria (16 isolates) and nonclinical sources comprising poultry and seafood from India (14 isolates). Analysis of PCR amplicons revealed that the genes , T, and were conserved in all the isolates except for two isolates obtained from clams, which did not have the and genes. In addition, the and genes were absent from all the tested isolates. This study provides insights into the distribution of selected T3SS genes among spp. isolated from clinical and raw animal food sources in Nigeria and India, respectively.
多种毒力基因编码细菌中的III型分泌系统（T3SS）。在[具体细菌名称未给出]中，这些基因位于致病岛1和致病岛2（SPI - 1和SPI - 2）中，它们促进细菌在巨噬细胞内的侵袭和复制，加重非伤寒[细菌名称未给出]感染的负担。在本研究中，我们调查了来自尼日利亚的30株实验室保存菌株（16株分离株）以及包括来自印度的家禽和海鲜等非临床来源（14株分离株）中选定的毒力编码基因的流行情况。PCR扩增子分析表明，除了从蛤中获得的两株分离株没有[具体基因名称未给出]和[具体基因名称未给出]基因外，[具体基因名称未给出]、T和[具体基因名称未给出]基因在所有分离株中均保守。此外，所有测试分离株均不存在[具体基因名称未给出]和[具体基因名称未给出]基因。本研究分别深入了解了从尼日利亚和印度的临床和生鲜动物食品来源分离的[细菌名称未给出]菌株中选定的T3SS基因的分布情况。
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