Li S, Borowitz M J
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Arch Pathol Lab Med. 2001 Jul;125(7):958-60. doi: 10.5858/2001-125-0958-CTCLLW.
Although there is a close association between Langerhans cell histiocytosis and malignant neoplasms, simultaneous occurrence of lymphoblastic lymphoma and Langerhans cell histiocytosis in the same lymph node is an extremely rare finding. Herein, we describe such a case in a 26-year-old woman who presented with progressive cervical lymphadenopathy. The lymphoma cells have an immature T-cell phenotype (terminal deoxynucleotidyl transferase(+), HLA-DR(+), CD34(+), CD38(+), and CD7(+)) with expression of both CD3 and CD79a on immunohistochemical stain. The Langerhans cells are present focally with the characteristic morphologic features and immunophenotype (CD1a(+) and S100(+)). The significance of CD79a coexpression in T-cell lymphoblastic lymphoma and the association between lymphoblastic lymphoma and Langerhans cell histiocytosis are discussed.
尽管朗格汉斯细胞组织细胞增多症与恶性肿瘤之间存在密切关联，但在同一淋巴结中同时出现淋巴细胞性淋巴瘤和朗格汉斯细胞组织细胞增多症是极其罕见的情况。在此，我们描述了一名26岁女性的此类病例，该患者表现为进行性颈部淋巴结病。淋巴瘤细胞具有不成熟的T细胞表型（末端脱氧核苷酸转移酶阳性、HLA-DR阳性、CD34阳性、CD38阳性和CD7阳性），免疫组化染色显示CD3和CD79a均表达。朗格汉斯细胞局灶性存在，具有特征性形态学特征和免疫表型（CD1a阳性和S100阳性）。本文讨论了CD79a在T细胞淋巴细胞性淋巴瘤中共表达的意义以及淋巴细胞性淋巴瘤与朗格汉斯细胞组织细胞增多症之间的关联。
