复发性喘息婴儿的血清总IgE水平与预后
Total serum IgE and outcome in infants with recurrent wheezing.
作者信息
Rusconi F, Patria M F, Cislaghi G U, Sideri S, Gagliardi L
机构信息
Department of Paediatrics I, University of Milan, Via Commenda 9, 20122 Milan, Italy.
出版信息
Arch Dis Child. 2001 Jul;85(1):23-5. doi: 10.1136/adc.85.1.23.
OBJECTIVE
To investigate the relation between total serum IgE at 0.5-3 and 3-6 years, and the risk of allergic sensitisation and persistent wheezing up to 8 years of age.
METHODS
Prospective follow up study of 45 infants with highly recurrent wheezing, no allergic symptoms, and negative skin tests.
RESULTS
In the last follow up year, 15 children still suffered from wheezing. Five wheeze-free and four episodically wheezing children had become sensitised. No association was found between early (0.5-3 years) IgE z scores and the recurrence of wheezing during follow up, or atopic sensitisation. IgE z scores at 3-6 years were significantly higher in children with positive skin tests (p = 0.013), but were still not associated with recurrence of wheezing.
CONCLUSIONS
In subjects with frequent early wheezing and no signs of atopy, early total serum IgE measurements are not predictive of outcome.
目的
研究0.5至3岁及3至6岁时血清总IgE与8岁前过敏致敏风险及持续性喘息之间的关系。
方法
对45名高度反复喘息、无过敏症状且皮肤试验阴性的婴儿进行前瞻性随访研究。
结果
在最后一次随访年中，15名儿童仍患有喘息。5名无喘息和4名偶发喘息儿童已致敏。未发现早期（0.5至3岁）IgE z评分与随访期间喘息复发或特应性致敏之间存在关联。皮肤试验阳性儿童在3至6岁时的IgE z评分显著更高（p = 0.013），但仍与喘息复发无关。
结论
在早期频繁喘息且无特应性体征的受试者中，早期血清总IgE测量不能预测预后。
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