宿主种族影响非霍奇金淋巴瘤亚型频率和爱泼斯坦-巴尔病毒关联率：马来西亚多民族患者群体的经验。

Host ethnicity influences non-Hodgkin's lymphoma subtype frequency and Epstein-Barr virus association rate: the experience of a multi-ethnic patient population in Malaysia.

作者信息

Peh S C

机构信息

Department of Pathology, University of Malaya, 50603 Kuala Lumpur, Malaysia.

出版信息

Histopathology. 2001 May;38(5):458-65. doi: 10.1046/j.1365-2559.2001.01104.x.

DOI:10.1046/j.1365-2559.2001.01104.x

PMID:11422484

Abstract

AIMS

The pattern of malignant lymphoma is known to vary in different populations. This study aims to elucidate the effect of ethnicity on subtype frequency of non-Hodgkin's lymphoma and EBV association rate.

METHODS AND RESULTS

A total of 232 reconfirmed lymphoma cases in Malaysian patients were retrieved from the archives in the Department of Pathology, University Hospital, Kuala Lumpur. There were 24 (10%) Hodgkin's and 208 (90%) non-Hodgkin's lymphomas, 173 of the latter were in adult group (aged > or = 15 years). The ethnic composition were 41 Malays, 107 Chinese, 21 Indians and four none of the above. A male : female ratio of 2.4 : 1 was observed. Complete immunohistochemical studies in 158 cases revealed 36 (23%) T-cell, 121 (76%) B-cell and one (1%) null-cell phenotype. Seventy-five percent of the T-cell lymphomas were peripheral T/NK-cell types. Among the classifiable lesions, low-grade/indolent lymphomas constituted 17%: 2% were the lymphocytic subtype and 10% were follicular lymphomas. Approximately one-third of the follicular lymphomas occurred in Indian patients. The largest group of high-grade lymphoma was diffuse large B-cell type (46%), followed by peripheral T/NK-cell (18%). A predominance of NK/T-cell lymphomas occurred in Chinese (5/7), and all were EBV associated. Burkitt's lymphoma accounted for 5% (eight cases), all were Chinese males, with a 38% EBV-association rate. The frequency of EBV-associated B-cell lymphoma is three times more common in Chinese than Malays. The EBV positivity rate among lymphomas in ethnic Malay, Chinese and Indian patients was 5%, 15% and 22%, respectively, and in T- and B-cell lymphomas was 36% and 7%, respectively.

CONCLUSIONS

This Malaysian series reveals differences in the subtype frequencies of non-Hodgkin's lymphomas and EBV association rate amongst patients of various ethnic groups residing in the same environment.

摘要

目的

已知恶性淋巴瘤的模式在不同人群中有所不同。本研究旨在阐明种族对非霍奇金淋巴瘤亚型频率及EBV关联率的影响。

方法与结果

从吉隆坡大学医院病理科档案中检索出232例重新确诊的马来西亚淋巴瘤患者病例。其中有24例（10%）霍奇金淋巴瘤和208例（90%）非霍奇金淋巴瘤，后者中的173例属于成人组（年龄≥15岁）。种族构成包括41名马来人、107名华人、21名印度人以及4名其他种族。观察到男女比例为2.4∶1。对158例病例进行的完整免疫组化研究显示，36例（23%）为T细胞表型、121例（76%）为B细胞表型、1例（1%）为裸细胞表型。75%的T细胞淋巴瘤为外周T/NK细胞类型。在可分类的病变中，低级别/惰性淋巴瘤占17%：2%为淋巴细胞亚型，10%为滤泡性淋巴瘤。约三分之一的滤泡性淋巴瘤发生在印度患者中。高级别淋巴瘤中最大的一组是弥漫性大B细胞型（46%），其次是外周T/NK细胞型（18%）。NK/T细胞淋巴瘤在华人中占优势（5/7），且均与EBV相关。伯基特淋巴瘤占5%（8例），均为中国男性，EBV关联率为38%。EBV相关B细胞淋巴瘤的发生率在华人中是马来人的三倍。马来人、华人及印度患者淋巴瘤中的EBV阳性率分别为5%、15%和22%，在T细胞和B细胞淋巴瘤中分别为36%和7%。