Poli V
Minerva Med. 1976 Oct 31;67(52):3409-12.
The anxiolytic and tranquillizing effect of a new compound called parsalmide was studied in a group of 20 patients suffering from medium anxiety neurosis. The new drug also possesses anti-inflammatory and analgesic effects. The technique employed was the double blind, between patients, crossover system and chlordiazepoxide was used for comparison purposes. Parsalmide proved to possess an anxiolytic-tranquillizing action comparable to that of chlordiazepoxide and, unlike the latter, was quite free from unpleasant side effects, such as somnolence and asthenia.
在一组20名中度焦虑神经症患者中研究了一种名为帕沙米德的新化合物的抗焦虑和镇静作用。这种新药还具有抗炎和镇痛作用。采用的技术是双盲、患者间交叉系统,并用氯氮卓作为对照。结果证明,帕沙米德具有与氯氮卓相当的抗焦虑-镇静作用,而且与氯氮卓不同的是,它完全没有嗜睡和乏力等不良副作用。