[西沙必利和雷尼替丁治疗新生儿胃食管反流时的QTc间期]

[QTc interval in newborns with gastroesophageal reflux treated with cisapride and ranitidine].

作者信息

Lista G, Maestri L, Meroni M, Massari D, Colli A, Porcelli F, Menchini M, Introvini P, Compagnoni G

机构信息

U.O di Terapia Intensiva Neonatale, Ospedale Buzzi, ICP Milano, Italia.

出版信息

Acta Biomed Ateneo Parmense. 2000;71 Suppl 1:633-6.

PMID:11424819

Abstract

Gastroesophageal reflux (GER) is very common in infants, especially in prematures and may be cause of gastrointestinal and cardiorespiratory symptoms. Cisapride, a prokinetic agent, is used in order to avoid the transient esophageal sphincter relaxation, but it is sometimes associated to transient prolongation of QT interval on EKG, especially with high dosage. The authors report the effects of cisapride therapy (0.8 mg/Kg/day) on QTc interval (QTc = QT interval corrected on heart frequency) in a pediatric population (50 infants) with GER. Results demonstrate the relatively safety of cisapride therapy at low dose also in the pediatric period.

摘要

胃食管反流（GER）在婴儿中非常常见，尤其是早产儿，可能是胃肠道和心肺症状的原因。西沙必利是一种促动力剂，用于避免食管下括约肌短暂松弛，但有时会与心电图上QT间期短暂延长有关，尤其是高剂量时。作者报告了西沙必利治疗（0.8mg/kg/天）对50名患有GER的儿科患者（婴儿）QTc间期（QTc=根据心率校正的QT间期）的影响。结果表明，低剂量西沙必利治疗在儿童期也相对安全。